Background:
Catalyzed organic reactions avoiding the use of metal salts, metal complexes
and organometallic compounds have tremendous applications especially within sensitive biological
systems. The current work is an effort towards metal and solvent-free organo-catalyzed reactions.
Objective:
Unprecedented, one-pot regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles
through azide-aldehyde (3+2) organo-click cycloaddition under metal and solvent-free conditions
is described.
Methods:
The method presents a convenient approach towards the synthesis of functionally versatile
1,4-disubstituted 1,2,3-triazoles from easily accessible substrates using recyclable 1,8-diazabicyclo[
5.4.0]undec-7-ene (DBU)-based ionic liquids as catalysts.
Results:
1,4-disubstituted 1,2,3-triazoles were obtained in moderate to excellent yield using azidealdehyde
(3+2) organo-click cycloaddition under metal and solvent-free conditions.
Conclusion:
The procedure reported herein for the synthesis of 1,4-disubstituted 1,2,3-triazoles is
straightforward, greener, devoid of tedious workups and chromatographic separation.